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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
Growth factor withdrawal is associated with a metabolic arrest that can result in apoptosis. Cell death is preceded by loss of outer mitochondrial membrane integrity and cytochrome c release. These mitochondrial events appear to follow a relative increase in mitochondrial membrane potential. This change in membrane potential results from the failure of the adenine nucleotide translocator (ANT)/voltage-dependent anion channel (VDAC) complex to maintain ATP/ADP exchange. Bcl-xL expression allows growth factor-deprived cells to maintain sufficient mitochondrial ATP/ADP exchange to sustain coupled respiration. These data demonstrate that mitochondrial adenylate transport is under active regulation. Efficient exchange of ADP for ATP is promoted by Bcl-xL expression permitting oxidative phosphorylation to be regulated by cellular ATP/ADP levels and allowing mitochondria to adapt to changes in metabolic demand.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Bcl2l1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Gramicidin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Porins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodamine 123,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Voltage-Dependent Anion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-67
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10078199-Adenosine Diphosphate,
pubmed-meshheading:10078199-Adenosine Triphosphate,
pubmed-meshheading:10078199-Animals,
pubmed-meshheading:10078199-Apoptosis,
pubmed-meshheading:10078199-Biological Transport, Active,
pubmed-meshheading:10078199-Caspases,
pubmed-meshheading:10078199-Fluorescent Dyes,
pubmed-meshheading:10078199-Gramicidin,
pubmed-meshheading:10078199-Hematopoietic Stem Cells,
pubmed-meshheading:10078199-Interleukin-3,
pubmed-meshheading:10078199-Membrane Potentials,
pubmed-meshheading:10078199-Mice,
pubmed-meshheading:10078199-Mitochondria,
pubmed-meshheading:10078199-Oxidative Phosphorylation,
pubmed-meshheading:10078199-Oxygen Consumption,
pubmed-meshheading:10078199-Porins,
pubmed-meshheading:10078199-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10078199-Recombinant Fusion Proteins,
pubmed-meshheading:10078199-Rhodamine 123,
pubmed-meshheading:10078199-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:10078199-Transfection,
pubmed-meshheading:10078199-Tumor Cells, Cultured,
pubmed-meshheading:10078199-Voltage-Dependent Anion Channels,
pubmed-meshheading:10078199-bcl-X Protein
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pubmed:year |
1999
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pubmed:articleTitle |
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.
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pubmed:affiliation |
Gwen Knapp Center, University of Chicago, Illinois 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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