Linked Life Data

10077015

Source:http://linkedlifedata.com/resource/pubmed/id/10077015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-5-4
pubmed:abstractText
Previous studies used manganese N,N'-bis-(pyridoxal 5-phosphate)ethylenediamine-N,N'-diacetic acid (MnDPDP) to detect myocardial ischemia at a dose of 0.4 mmol/kg with spin echo imaging. The purpose of this study was to detect acute myocardial ischemia using MnDPDP at a dose range near that approved for hepatobiliary imaging (0.005 mmol/kg) in conjunction with inversion recovery echoplanar imaging (IR EPI). Regional ischemia was produced in 26 rats by occluding the left coronary artery for 20-30 minutes before imaging. Consecutive 32 IR EP images (inversion time [TI]/TR/TE 700/2000/10 msec) were obtained to monitor the first pass of MnDPDP at four incremental doses (0.005, 0.01, 0.02, or 0.04 mmol/kg, n = 6-8). MnDPDP produced dose-dependent enhancement of left ventricular blood and normal myocardium, but not ischemic myocardium. Quantitative analysis revealed a difference in signal intensities (P<0.05) between normal and ischemic myocardium at the time of peak enhancement in all groups. However, differential enhancement between normal and ischemic myocardium produced clear visual delineation of the ischemic region only at doses > or =0.01 mmol/kg. In conclusion, acute myocardial ischemia can be detected with IR EPI using doses close to the clinically approved dose of MnDPDP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1053-1807
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Detection of acute myocardial ischemia using first-pass dynamics of MnDPDP on inversion recovery echoplanar imaging.
pubmed:affiliation
Department of Radiology, University of California at San Francisco 94143-0628, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't