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rdf:type |
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lifeskim:mentions |
umls-concept:C0002475,
umls-concept:C0007600,
umls-concept:C0008838,
umls-concept:C0024623,
umls-concept:C0025932,
umls-concept:C0086418,
umls-concept:C0205195,
umls-concept:C0205221,
umls-concept:C0334227,
umls-concept:C0442034,
umls-concept:C0764876,
umls-concept:C1280500,
umls-concept:C1456501,
umls-concept:C1513016
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pubmed:issue |
1
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|
pubmed:dateCreated |
1999-3-30
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|
pubmed:abstractText |
R-94138, a matrix metalloproteinase inhibitor, was examined for the ability to prevent peritoneal dissemination of a human gastric cancer xenograft, TMK-1. When the supernatant of a co-culture of TMK-1 cells and human normal fibroblast cells was subjected to gelatin zymography, it was clear that the protein expression of MMP-2 had been inhibited by R-94138. When TMK-1 was injected intraperitoneally (i.p.) into nude mice at 5 x 10(5) cells/body, the resulting peritoneal dissemination mimicked clinical carcinomatous peritonitis. When the maximum tolerated dose of mitomycin C (MMC) or cisplatin (DDP) was given 12 h after the tumor inoculation, peritoneal dissemination was completely inhibited, while the effect of R-94138 was limited when it was given i.p. at a dose of 20 mg/kg in a schedule of q.d. x 5 starting 12 h after tumor injection. MMC and DDP also suppressed peritoneal dissemination when they were administered 1 week after the tumor inoculation at a single dose of 2 and 3 mg/kg i.p., respectively. R-94138 inhibited peritoneal dissemination when it was administered i.p. at a dose of 30 mg/kg in a schedule of q.d. x 5 starting from 1 week after tumor injection. The combination of MMC and R-94138 increased the preventive effect on peritoneal dissemination. R-94138 seems to be a promising candidate to prevent peritoneal dissemination of gastric cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0910-5050
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pubmed:author |
pubmed-author:IgarashiNN,
pubmed-author:KitajimaMM,
pubmed-author:KobayashiTT,
pubmed-author:KubotaTT,
pubmed-author:KumaiKK,
pubmed-author:MatsuzakiS WSW,
pubmed-author:OtaniYY,
pubmed-author:TamakiKK,
pubmed-author:TanzawaKK,
pubmed-author:TeramotoTT,
pubmed-author:WatanabeMM
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10076574-Acetamides,
pubmed-meshheading:10076574-Animals,
pubmed-meshheading:10076574-Antineoplastic Agents,
pubmed-meshheading:10076574-Cisplatin,
pubmed-meshheading:10076574-Gelatinases,
pubmed-meshheading:10076574-Humans,
pubmed-meshheading:10076574-Male,
pubmed-meshheading:10076574-Matrix Metalloproteinase 2,
pubmed-meshheading:10076574-Metalloendopeptidases,
pubmed-meshheading:10076574-Mice,
pubmed-meshheading:10076574-Mice, Nude,
pubmed-meshheading:10076574-Mitomycin,
pubmed-meshheading:10076574-Neoplasm Metastasis,
pubmed-meshheading:10076574-Peritoneal Neoplasms,
pubmed-meshheading:10076574-Stomach Neoplasms,
pubmed-meshheading:10076574-Transplantation, Heterologous,
pubmed-meshheading:10076574-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Preventive effect of matrix metalloproteinase inhibitor, R-94138, in combination with mitomycin C or cisplatin on peritoneal dissemination of human gastric cancer cell line TMK-1 in nude mice.
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pubmed:affiliation |
Department of Surgery, School of Medicine, Keio University, Tokyo.
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pubmed:publicationType |
Journal Article
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