Linked Life Data

10075026

Source:http://linkedlifedata.com/resource/pubmed/id/10075026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-4-13
pubmed:abstractText
Eosinophils are important effectors of the non-specific immune response and we studied whether perturbations in the production of the type 2 cytokine, interleukin-5 (IL-5), could account for the variations in eosinophil counts observed in human immunodeficiency virus (HIV) infection. HIV-infected patients without helminthiasis were investigated in a cross-sectional study in West Africa. Eosinophil counts were significantly higher in CDC-B patients than in controls, but were dramatically decreased at the CDC-C stage. Phorbol 12-myristate 13-acetate (PMA)+ ionomycin-induced IL-5 production by peripheral blood mononuclear cells (PBMC) was decreased from the A stage of the disease, and significant correlations were observed between IL-5 production and eosinophil counts in tuberculosis (TB)-negative HIV-1-positive, TB-positive HIV-1-positive and TB-positive HIV-negative patient groups. Nevertheless, the production of IL-5 was not decreased in HIV-positive patients with TB, in contrast to HIV-positive patients without TB presenting with the same ranges of CD4+ counts. Our data suggest that, during HIV infection, the impairment in IL-5 production is one of the factors associated with the 'paradoxal' eosinopenia observed in tropical areas, but that IL-5 production during active TB is compensated by cellular subsets, yet to be identified.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Acquired Immunodeficiency Syndrome, http://linkedlifedata.com/resource/pubmed/keyword/Africa, http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Burkina Faso, http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/French Speaking Africa, http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections, http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY, http://linkedlifedata.com/resource/pubmed/keyword/Immunologic Factors, http://linkedlifedata.com/resource/pubmed/keyword/Infections, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research Report, http://linkedlifedata.com/resource/pubmed/keyword/TUBERCULOSIS, http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Western Africa
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-9
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: Eosinophils are important effectors of nonspecific immune response, with eosinophilia being a classic sign of helminthic infection, allergies, and some inflammatory processes. The authors explored whether perturbations in the production of interleukin-5 (IL-5) could account for the variations in eosinophil counts seen in HIV infection. The 491 study subjects were recruited between 1993 and 1995 in Bobo-Dioulasso, Burkina Faso. Eosinophil counts were significantly higher in CDC-B AIDS patients than in controls, but were dramatically lower among CDC-C stage subjects. Phorbol 12-myristate 13-acetate (PMA)+ionomycin-induced IL-5 production by peripheral blood mononuclear cells (PBMC) was decreased from the A stage of the disease, and significant correlations were observed between IL-5 production and eosinophil counts in tuberculosis (TB)-negative HIV-1-positive, TB-positive HIV-1-positive, and TB-positive HIV-negative patient groups. The production of IL-5 was not decreased among HIV-positive patients with TB, in contrast to HIV-positive patients without TB presenting with the same ranges of CD4+ counts. These data suggest that during HIV infection, impairment in IL-5 production is one factor associated with the paradoxal eosinopenia observed in tropical areas, but that IL-5 production during active TB is compensated by as yet unidentified cellular subsets.
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Relationship between interleukin-5 production and variations in eosinophil counts during HIV infection in West Africa: influence of Mycobacterium tuberculosis infection.
pubmed:affiliation
Centre MURAZ, Organisation de Coordination et de Coopération pour la lutte contre les Grandes endémies, Burkina Faso, West Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't