Source:http://linkedlifedata.com/resource/pubmed/id/10075023
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
1999-4-13
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| pubmed:abstractText |
The photosensitizer benzoporphyrin-derivative monoacid ring A (BPD-MA, verteporfin), in combination with visible light irradiation, a clinical procedure termed photodynamic therapy (PDT), has immunomodulatory activity in various mouse models. We studied the impact of BPD-MA and light upon DBA/2 mouse splenic dendritic cells (DC), a potent antigen-presenting cell (APC) type. DC treated with nanomolar amounts of BPD-MA and 690 nm wavelength light had a reduced capacity to stimulate the proliferation of alloreactive T cells. Treatment with BPD-MA and light reduced DC levels of major histocompatibility (MHC) Class I and II antigens, intercellular adhesion molecule-1 (ICAM-1, CD54), the costimulatory B7-1 (CD80) and B7-2 (CD86) molecules, leucocyte common antigen CD45, the apoptosis-regulating Fas (CD95) receptor and the integrin CD11c. In contrast, DC expression of leucocyte function-associated-1 (LFA-1, CD11a), Mac-1 (CD11b), integrin beta2 chain (CD18) and the DEC-205 receptor increased, while CD40 levels were relatively unchanged 24 h after the treatment. MHC Class I and ICAM-1 levels decreased to 40% of control levels within 2 h following the photodynamic treatment. In the absence of light, BPD-MA did not affect DC receptor levels. Changes in DC receptor levels produced by BPD-MA and red light were similar to those produced by ultraviolet B light irradiation. The photodynamic treatment of activated splenic B cells, a separate APC class, had little effect upon receptor expression, except that MHC Class II levels were moderately decreased 24 h later. Changes in DC receptor expression may contribute to the immunomodulatory action of PDT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Photosensitizing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Porphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/benzoporphyrin D
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0300-9475
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
49
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
184-92
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| pubmed:dateRevised |
2005-10-1
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| pubmed:meshHeading |
pubmed-meshheading:10075023-Animals,
pubmed-meshheading:10075023-Antigens, CD,
pubmed-meshheading:10075023-B-Lymphocytes,
pubmed-meshheading:10075023-Cell Survival,
pubmed-meshheading:10075023-Cells, Cultured,
pubmed-meshheading:10075023-Dendritic Cells,
pubmed-meshheading:10075023-Histocompatibility Antigens Class I,
pubmed-meshheading:10075023-Histocompatibility Antigens Class II,
pubmed-meshheading:10075023-Light,
pubmed-meshheading:10075023-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:10075023-Male,
pubmed-meshheading:10075023-Mice,
pubmed-meshheading:10075023-Mice, Inbred C57BL,
pubmed-meshheading:10075023-Mice, Inbred DBA,
pubmed-meshheading:10075023-Photochemotherapy,
pubmed-meshheading:10075023-Photosensitizing Agents,
pubmed-meshheading:10075023-Porphyrins,
pubmed-meshheading:10075023-Receptors, Cell Surface,
pubmed-meshheading:10075023-Spleen,
pubmed-meshheading:10075023-Ultraviolet Rays
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| pubmed:year |
1999
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| pubmed:articleTitle |
Photodynamic alteration of the surface receptor expression pattern of murine splenic dendritic cells.
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| pubmed:affiliation |
QLT PhotoTherapeutics, Inc., Vancouver, Canada.
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| pubmed:publicationType |
Journal Article
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