| pubmed-article:10075018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C1444754 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C1865782 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:10075018 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:10075018 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10075018 | pubmed:dateCreated | 1999-4-13 | lld:pubmed |
| pubmed-article:10075018 | pubmed:abstractText | T cells are essential in the initiation and maintenance of immune responses. Specific interaction between T cells and a presumptive antigen occurs through recognition of an MHC-peptide complex by the T-cell receptor (TCR). The complementarity-determining region (CDR) 3 of the TCR has direct contact with the peptide. Here we describe CDR3 length variability of six different TCRBV gene families of CD4+ and CD8+ umbilical cord (UC) and peripheral blood (PB) T cells. Amplified products spanning the TCR CDR3 regions from CD4+ PB, CD4+ UC and CD8+ UC blood T cells typically displayed Gaussian-like distributions. In contrast, profound and frequent perturbations were recorded in CD8+ PB lymphocytes, with a non-Gaussian pattern in more than half of the samples studied. A substantial portion of the perturbed CD8+ subsets were clonal or oligoclonal, as determined by CDR3-length restriction, TCRBJ gene usage and nucleotide sequencing. This implies that the conditions for shaping and maintenance of the peripheral TCR repertoire are profoundly different for CD8+ and CD4+ T cells. | lld:pubmed |
| pubmed-article:10075018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10075018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10075018 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10075018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10075018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10075018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10075018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10075018 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10075018 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:AnderssonRR | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:RossiPP | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:WigzellHH | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:GrunewaldJJ | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:HalapiEE | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:Jeddi-Tehrani... | lld:pubmed |
| pubmed-article:10075018 | pubmed:author | pubmed-author:BlücherAA | lld:pubmed |
| pubmed-article:10075018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10075018 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:10075018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10075018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10075018 | pubmed:pagination | 149-54 | lld:pubmed |
| pubmed-article:10075018 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:meshHeading | pubmed-meshheading:10075018... | lld:pubmed |
| pubmed-article:10075018 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10075018 | pubmed:articleTitle | Diverse T-cell receptor CDR3 length patterns in human CD4+ and CD8+ T lymphocytes from newborns and adults. | lld:pubmed |
| pubmed-article:10075018 | pubmed:affiliation | Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:10075018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10075018 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10075018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10075018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10075018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10075018 | lld:pubmed |
