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pubmed-article:10073515pubmed:abstractTextThe cytochrome P450 CYP2C9 is responsible for the metabolism of S-warfarin. Two known allelic variants CYP2C9*2 and CYP2C9*3 differ from the wild type CYP2C9*1 by a single aminoacid substitution in each case. The allelic variants are associated with impaired hydroxylation of S-warfarin in in-vitro expression systems. We have studied the effect of CYP2C9 polymorphism on the in-vivo warfarin dose requirement.lld:pubmed
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pubmed-article:10073515pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10073515pubmed:articleTitleAssociation of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications.lld:pubmed
pubmed-article:10073515pubmed:affiliationDepartment of Medicine, University of Newcastle upon Tyne Medical School, UK.lld:pubmed
pubmed-article:10073515pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10073515pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:10073515pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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