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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9154
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pubmed:dateCreated |
1999-4-2
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pubmed:abstractText |
The cytochrome P450 CYP2C9 is responsible for the metabolism of S-warfarin. Two known allelic variants CYP2C9*2 and CYP2C9*3 differ from the wild type CYP2C9*1 by a single aminoacid substitution in each case. The allelic variants are associated with impaired hydroxylation of S-warfarin in in-vitro expression systems. We have studied the effect of CYP2C9 polymorphism on the in-vivo warfarin dose requirement.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
353
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
717-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10073515-Aged,
pubmed-meshheading:10073515-Aged, 80 and over,
pubmed-meshheading:10073515-Anticoagulants,
pubmed-meshheading:10073515-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:10073515-Case-Control Studies,
pubmed-meshheading:10073515-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10073515-Dose-Response Relationship, Drug,
pubmed-meshheading:10073515-Female,
pubmed-meshheading:10073515-Genotype,
pubmed-meshheading:10073515-Hemorrhage,
pubmed-meshheading:10073515-Humans,
pubmed-meshheading:10073515-International Normalized Ratio,
pubmed-meshheading:10073515-Male,
pubmed-meshheading:10073515-Middle Aged,
pubmed-meshheading:10073515-Point Mutation,
pubmed-meshheading:10073515-Polymorphism, Genetic,
pubmed-meshheading:10073515-Steroid 16-alpha-Hydroxylase,
pubmed-meshheading:10073515-Steroid Hydroxylases,
pubmed-meshheading:10073515-Warfarin
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pubmed:year |
1999
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pubmed:articleTitle |
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications.
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pubmed:affiliation |
Department of Medicine, University of Newcastle upon Tyne Medical School, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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