Source:http://linkedlifedata.com/resource/pubmed/id/10072502
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1999-4-14
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pubmed:abstractText |
IL-15 is a T cell growth factor that shares many biological activities with IL-2 and uses the same beta/gamma polypeptides of the IL-2R complex for signal transduction. Accumulating evidence implicates an important role for this cytokine in the inflammatory response of the host. Consistent with such a role, IL-15 has been shown to be a chemoattractant for T lymphocytes, NK cells, and neutrophils. Extending these observations, we now show that IL-15 is a potent inducer of CC-, CXC-, and C-type chemokines in T lymphocytes. In addition, we demonstrate that IL-15 induces CC chemokine receptors, but not CXC chemokine receptors, in a dose-dependent manner. Thus, our findings suggest that the proinflammatory effects of IL-15 at least in part may be due to the induction of chemokines and their receptors in T cells. Furthermore, we demonstrate that IL-15 promotes entry and replication of macrophage-tropic HIV in T lymphocytes and suggest a plausible mechanism by which IL-15, a cytokine that is elevated in HIV-infected individuals, may promote the transition of HIV displaying the M-tropic phenotype primarily associated with the initial transmission into the T cell-tropic phenotype that predominates as the disease progresses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2606-12
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10072502-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10072502-Chemokine CCL5,
pubmed-meshheading:10072502-Chemokines,
pubmed-meshheading:10072502-Humans,
pubmed-meshheading:10072502-Interleukin-15,
pubmed-meshheading:10072502-Interleukin-2,
pubmed-meshheading:10072502-RNA, Messenger,
pubmed-meshheading:10072502-Receptors, CCR5,
pubmed-meshheading:10072502-Receptors, Chemokine,
pubmed-meshheading:10072502-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
IL-15 induces the expression of chemokines and their receptors in T lymphocytes.
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pubmed:affiliation |
Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA. lperera@atlas.niaid.nih.gov
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pubmed:publicationType |
Journal Article
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