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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-4-14
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pubmed:abstractText |
Our understanding of how RB and E2F-1 function has progressed significantly from the model in which RB negatively regulates expression of genes required for S phase by binding to and inhibiting E2F-1. Both RB and E2F-1 have been shown recently to possess additional properties and mechanisms of regulation relevant to developmental and tumorigenic processes. In particular, it is now realised that RB has E2F-independent tumor suppressor functions which rely upon the ability of RB to induce differentiation. For its part, E2F-1 is unique amongst E2F family members in its capacity to induce apoptosis and this function is clearly relevant to our appreciation of E2F-1 as a conditional tumor suppressor. E2F-1 can induce both apoptosis and S-phase transition and whether E2F-1 acts as an oncogene or a tumor-suppressor gene may depend on the extent to which E2F-1 induces apoptosis as opposed to G1/S transition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arid4a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/E2F1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor DP1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0959-437X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10072353-Animals,
pubmed-meshheading:10072353-Apoptosis,
pubmed-meshheading:10072353-Carrier Proteins,
pubmed-meshheading:10072353-Cell Cycle Proteins,
pubmed-meshheading:10072353-Cell Differentiation,
pubmed-meshheading:10072353-Cell Division,
pubmed-meshheading:10072353-DNA-Binding Proteins,
pubmed-meshheading:10072353-E2F Transcription Factors,
pubmed-meshheading:10072353-E2F1 Transcription Factor,
pubmed-meshheading:10072353-Gene Expression Regulation, Developmental,
pubmed-meshheading:10072353-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10072353-Mice,
pubmed-meshheading:10072353-Neoplasms,
pubmed-meshheading:10072353-Retinoblastoma Protein,
pubmed-meshheading:10072353-Retinoblastoma-Binding Protein 1,
pubmed-meshheading:10072353-Transcription Factor DP1,
pubmed-meshheading:10072353-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
pRb and E2f-1 in mouse development and tumorigenesis.
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pubmed:affiliation |
Department of Molecular & Cellular Pathology, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK. k.f.macleod@dundee.ac.uk
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pubmed:publicationType |
Journal Article,
Review
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