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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-3-25
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pubmed:abstractText |
Cathepsins have been implicated in the degradation of proteins destined for the MHC class II processing pathway and in the proteolytic removal of invariant chain (Ii), a critical regulator of MHC class II function. Mice lacking the lysosomal cysteine proteinase cathepsin S (catS) demonstrated a profound inhibition of Ii degradation in professional APC in vivo. A marked variation in the generation of MHC class II-bound Ii fragments and presentation of exogenous proteins was observed between B cells, dendritic cells, and macrophages lacking catS. CatS-deficient mice showed diminished susceptibility to collagen-induced arthritis, suggesting a potential therapeutic target for regulation of immune responsiveness.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:BrissetteW HWH,
pubmed-author:ClarkeS RSR,
pubmed-author:EastmanS ESE,
pubmed-author:ElliottE AEA,
pubmed-author:GriffithsR JRJ,
pubmed-author:HowardE DED,
pubmed-author:LiemR KRK,
pubmed-author:McNeishJ DJD,
pubmed-author:NakagawaT YTY,
pubmed-author:PetrushovaNN,
pubmed-author:RosloniecE FEF,
pubmed-author:RudenskyA YAY,
pubmed-author:StockJJ
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-17
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10072073-Animals,
pubmed-meshheading:10072073-Antigen Presentation,
pubmed-meshheading:10072073-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:10072073-Arthritis,
pubmed-meshheading:10072073-Cathepsins,
pubmed-meshheading:10072073-Collagen,
pubmed-meshheading:10072073-Dendritic Cells,
pubmed-meshheading:10072073-Drug Design,
pubmed-meshheading:10072073-Gene Targeting,
pubmed-meshheading:10072073-Histocompatibility Antigens Class II,
pubmed-meshheading:10072073-Macrophages,
pubmed-meshheading:10072073-Mice,
pubmed-meshheading:10072073-Mice, Knockout,
pubmed-meshheading:10072073-Spleen
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pubmed:year |
1999
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pubmed:articleTitle |
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
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pubmed:affiliation |
Howard Hughes Medical Institute, and Department of Immunology, University of Washington School of Medicine, Seattle 98115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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