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pubmed-article:10071976pubmed:abstractTextWe have reported a 6-fold difference in the topotecan (TPT) lactone systemic exposure achieving a complete response in the human neuroblastoma xenografts NB-1691 and NB-1643. However, the relationship between tumor extracellular fluid (ECF) exposure to TPT and the antitumor activity in xenograft and in vitro models has not been established.lld:pubmed
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pubmed-article:10071976pubmed:articleTitleRelationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines.lld:pubmed
pubmed-article:10071976pubmed:affiliationDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.lld:pubmed
pubmed-article:10071976pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10071976pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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