|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0015349,
umls-concept:C0027651,
umls-concept:C0027819,
umls-concept:C0086418,
umls-concept:C0146224,
umls-concept:C0332157,
umls-concept:C0439849,
umls-concept:C0522537,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1999-3-23
|
|
pubmed:abstractText |
We have reported a 6-fold difference in the topotecan (TPT) lactone systemic exposure achieving a complete response in the human neuroblastoma xenografts NB-1691 and NB-1643. However, the relationship between tumor extracellular fluid (ECF) exposure to TPT and the antitumor activity in xenograft and in vitro models has not been established.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
269-76
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10071976-Animals,
pubmed-meshheading:10071976-Chromatography, High Pressure Liquid,
pubmed-meshheading:10071976-Extracellular Space,
pubmed-meshheading:10071976-Female,
pubmed-meshheading:10071976-Humans,
pubmed-meshheading:10071976-Immunosuppression,
pubmed-meshheading:10071976-Mice,
pubmed-meshheading:10071976-Mice, Inbred CBA,
pubmed-meshheading:10071976-Microdialysis,
pubmed-meshheading:10071976-Models, Biological,
pubmed-meshheading:10071976-Neuroblastoma,
pubmed-meshheading:10071976-Thymectomy,
pubmed-meshheading:10071976-Tissue Distribution,
pubmed-meshheading:10071976-Topotecan,
pubmed-meshheading:10071976-Transplantation, Heterologous,
pubmed-meshheading:10071976-Tumor Cells, Cultured,
pubmed-meshheading:10071976-Whole-Body Irradiation
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines.
|
|
pubmed:affiliation |
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
