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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-3-16
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pubmed:abstractText |
Mycophenolate mofetil (MMF) is an inhibitor of purine nucleotide de novo synthesis leading to impaired proliferation of activated lymphocytes. Studies in animals show a synergistic effect of MMF and cyclosporine (CsA) in preventing acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation. We performed a pilot study evaluating the feasibility of the combined application of MMF and CsA as GVHD prophylaxis after allogeneic blood stem cell transplantation. Toxicity and the bioavailability of MMF in this setting were investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
499-504
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10071016-Adult,
pubmed-meshheading:10071016-Cyclosporine,
pubmed-meshheading:10071016-Drug Therapy, Combination,
pubmed-meshheading:10071016-Female,
pubmed-meshheading:10071016-Follow-Up Studies,
pubmed-meshheading:10071016-Graft vs Host Disease,
pubmed-meshheading:10071016-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10071016-Humans,
pubmed-meshheading:10071016-Immunosuppressive Agents,
pubmed-meshheading:10071016-Male,
pubmed-meshheading:10071016-Middle Aged,
pubmed-meshheading:10071016-Mycophenolic Acid,
pubmed-meshheading:10071016-Pilot Projects,
pubmed-meshheading:10071016-Retrospective Studies,
pubmed-meshheading:10071016-Transplantation, Homologous
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pubmed:year |
1999
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pubmed:articleTitle |
Mycophenolate mofetil and cyclosporine as graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation.
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pubmed:affiliation |
Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
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pubmed:publicationType |
Journal Article
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