Source:http://linkedlifedata.com/resource/pubmed/id/10070966
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
1999-3-22
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| pubmed:abstractText |
These studies examined the composition of lymphocytes within the lung after the introduction of tumor cells that metastasize to the lung in rats. i.v. delivery of MADB106 tumor cells into syngeneic Fischer 344 rats caused dose- and time-dependent development of lung tumors, with surface metastases evident 7 days after injection and markedly increased 11 days after injection. The total number of lymphocytes recovered from the lung was increased 11 days after injection but not 7 days after injection. When lymphocytes from the lung, spleen, and blood were subjected to fluorescence-activated cell sorting analysis, the most conspicuous change was an increase in the percentage of CD45RA+ cells (i.e., B lymphocytes in the rat) in the lung, with no changes seen in the percentage of natural killer (NKR-P1+), CD4+, or CD8+ cells in the lung. Analysis of the time course showed that B lymphocytes increased in the lung soon after i.v. tumor injection, with an initial peak seen 6 h after injection. Rapid influx of B lymphocytes into lung after i.v. tumor cell injection was also observed in another syngeneic tumor model, i.e., after injection of CC531 cells into WAG rats. To determine whether the influx of B lymphocytes into the lung might participate in tumor surveillance, a high dose of antibody (100 microg) to rat B lymphocytes was given to immunoneutralize these cells; this produced an increase in lung tumors in both models. Finally, Fischer 344 rats were given a s.c. injection of MADB106 tumor cells that made them resistant to lung tumors when given a later i.v. injection of these tumor cells. These animals were found to have an elevated level of B lymphocytes residing in the lung associated with the resistance to lung tumor. These findings suggest that early responses of B lymphocytes are important in protection against tumor development in two rat models of cancer.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
59
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1080-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10070966-Adenocarcinoma,
pubmed-meshheading:10070966-Animals,
pubmed-meshheading:10070966-B-Lymphocytes,
pubmed-meshheading:10070966-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10070966-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10070966-Female,
pubmed-meshheading:10070966-Immunologic Surveillance,
pubmed-meshheading:10070966-Killer Cells, Natural,
pubmed-meshheading:10070966-Lung Neoplasms,
pubmed-meshheading:10070966-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:10070966-Male,
pubmed-meshheading:10070966-Mammary Neoplasms, Experimental,
pubmed-meshheading:10070966-Neoplasm Metastasis,
pubmed-meshheading:10070966-Rats,
pubmed-meshheading:10070966-Rats, Inbred F344,
pubmed-meshheading:10070966-Rats, Inbred Strains,
pubmed-meshheading:10070966-Species Specificity,
pubmed-meshheading:10070966-Spleen,
pubmed-meshheading:10070966-T-Lymphocyte Subsets
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| pubmed:year |
1999
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| pubmed:articleTitle |
Evidence for involvement of B lymphocytes in the surveillance of lung metastasis in the rat.
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| pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|