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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
522-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10069917-Animals,
pubmed-meshheading:10069917-Aorta, Abdominal,
pubmed-meshheading:10069917-Aortic Aneurysm, Abdominal,
pubmed-meshheading:10069917-Collagen,
pubmed-meshheading:10069917-Desmosine,
pubmed-meshheading:10069917-Disease Models, Animal,
pubmed-meshheading:10069917-Elastin,
pubmed-meshheading:10069917-Hydroxamic Acids,
pubmed-meshheading:10069917-Hydroxyproline,
pubmed-meshheading:10069917-Injections, Intra-Arterial,
pubmed-meshheading:10069917-Injections, Subcutaneous,
pubmed-meshheading:10069917-Male,
pubmed-meshheading:10069917-Metalloendopeptidases,
pubmed-meshheading:10069917-Pancreatic Elastase,
pubmed-meshheading:10069917-Pharmaceutical Vehicles,
pubmed-meshheading:10069917-Protease Inhibitors,
pubmed-meshheading:10069917-Rats,
pubmed-meshheading:10069917-Rats, Wistar
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pubmed:year |
1999
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pubmed:articleTitle |
Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908).
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pubmed:affiliation |
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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