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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
Hyperhomocysteinemia is a major and independent risk factor for vascular disease. The mechanisms by which homocysteine promotes atherosclerosis are not well understood. We hypothesized that elevated homocysteine concentrations are associated with rapid onset endothelial dysfunction, which is mediated through oxidant stress mechanisms and can be inhibited by the antioxidant vitamin C. Methods and
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1156-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10069782-Adult,
pubmed-meshheading:10069782-Ascorbic Acid,
pubmed-meshheading:10069782-Blood Flow Velocity,
pubmed-meshheading:10069782-Brachial Artery,
pubmed-meshheading:10069782-Endothelium, Vascular,
pubmed-meshheading:10069782-Female,
pubmed-meshheading:10069782-Homocysteine,
pubmed-meshheading:10069782-Humans,
pubmed-meshheading:10069782-Hyperhomocysteinemia,
pubmed-meshheading:10069782-Male,
pubmed-meshheading:10069782-Methionine,
pubmed-meshheading:10069782-Middle Aged,
pubmed-meshheading:10069782-Oxidative Stress,
pubmed-meshheading:10069782-Time Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy.
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pubmed:affiliation |
National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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