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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-8-17
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pubmed:abstractText |
Trypanosoma cruzi was transformed with the Plasmodium yoelii gene encoding the circum-sporozoite (CS) protein, which contains the well-characterized CD8+ T cell epitope, SYVPSAEQI. In vivo and in vitro assays indicated that cells infected with the transformed T. cruzi could process and present this malaria parasite-derived class I MHC-restricted epitope. Immunization of mice with recombinant influenza and vaccinia viruses expressing the SYVPSAEQI epitope induced a large number of specific CD8+ T cells that strongly suppressed parasitemia and conferred complete protection against the acute T. cruzi lethal infection. CD8+ T cells mediated this immunity as indicated by the unrelenting parasitemia and high mortality observed in immunized mice treated with anti-CD8 antibody. This study demonstrated, for the first time, that vaccination of mice with vectors designed to induce CD8+ T cells is effective against T. cruzi infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-41
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pubmed:dateRevised |
2006-4-21
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pubmed:meshHeading |
pubmed-meshheading:10069411-Animals,
pubmed-meshheading:10069411-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10069411-Chagas Disease,
pubmed-meshheading:10069411-Epitopes, T-Lymphocyte,
pubmed-meshheading:10069411-Genetic Vectors,
pubmed-meshheading:10069411-Immunization,
pubmed-meshheading:10069411-Mice,
pubmed-meshheading:10069411-Mice, Inbred BALB C,
pubmed-meshheading:10069411-Orthomyxoviridae,
pubmed-meshheading:10069411-Plasmodium yoelii,
pubmed-meshheading:10069411-Protozoan Proteins,
pubmed-meshheading:10069411-Recombinant Proteins,
pubmed-meshheading:10069411-Transformation, Genetic,
pubmed-meshheading:10069411-Trypanosoma cruzi,
pubmed-meshheading:10069411-Vaccinia virus
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pubmed:year |
1999
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pubmed:articleTitle |
Induction of CD8+ T cell-mediated protective immunity against Trypanosoma cruzi.
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pubmed:affiliation |
Department of Parasitology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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