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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1999-6-21
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pubmed:abstractText |
The objective of this study was to examine the antinociceptive effects of peripherally restricted kappa-opioid receptor agonists (ORAs) in a rat model of inflammatory bowel disease produced by intracolonic instillation of trinitrobenzine sulfonic acid (TNBS). Antinociceptive effects of mu-(morphine) and kappa-ORAs (EMD 61,753 and ICI 204,488) were evaluated in a behavioral model of visceral nociception. The effects of these agonists and a delta-ORA (SNC 80) on responses of pelvic nerve afferent fibers innervating the colon were also tested. In the behavioral study, systemic injections of morphine and both kappa-ORAs dose-dependently inhibited the visceromotor response to colorectal distension in rats with uninflamed or inflamed colons. The inhibitory effects of kappa-ORAs, but not morphine, were significantly greater in rats with colons inflamed 4 days previously by TNBS. A mu-receptor-selective dose (30 microg/kg) of naloxone methiodide (NLXM) blocked the inhibitory effect of morphine, but not of EMD 61,753. In the single-fiber study, neither morphine nor the delta-ORA SNC 80 attenuated the responses of pelvic nerve afferent fibers, whereas kappa-ORAs dose-dependently inhibited responses of pelvic nerve afferent fibers with significantly greater potency in the inflamed colon. Pretreatment with a non-opioid receptor-selective dose (2 mg/kg) of NLXM produced a rightward shift in the dose-response function of EMD 61,753. The greater potency of kappa-ORAs in the TNBS-inflamed condition suggests a peripheral upregulation of kappa-opioid receptors in colonic inflammation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(alpha-(4-allyl-2,5-dimethyl-1-pip...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetamides,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/EMD 61753,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenesulfonic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3959
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-85
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10068163-Acetamides,
pubmed-meshheading:10068163-Action Potentials,
pubmed-meshheading:10068163-Analgesics, Opioid,
pubmed-meshheading:10068163-Animals,
pubmed-meshheading:10068163-Benzamides,
pubmed-meshheading:10068163-Chronic Disease,
pubmed-meshheading:10068163-Colitis,
pubmed-meshheading:10068163-Colon,
pubmed-meshheading:10068163-Electrophysiology,
pubmed-meshheading:10068163-Male,
pubmed-meshheading:10068163-Morphine,
pubmed-meshheading:10068163-Naloxone,
pubmed-meshheading:10068163-Narcotic Antagonists,
pubmed-meshheading:10068163-Nerve Fibers,
pubmed-meshheading:10068163-Neurons, Afferent,
pubmed-meshheading:10068163-Pain Measurement,
pubmed-meshheading:10068163-Piperazines,
pubmed-meshheading:10068163-Pressure,
pubmed-meshheading:10068163-Pyrrolidines,
pubmed-meshheading:10068163-Rats,
pubmed-meshheading:10068163-Rats, Sprague-Dawley,
pubmed-meshheading:10068163-Receptors, Opioid, kappa,
pubmed-meshheading:10068163-Rectum,
pubmed-meshheading:10068163-Trinitrobenzenesulfonic Acid
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pubmed:year |
1999
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pubmed:articleTitle |
Effects of kappa opioids in the inflamed rat colon.
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pubmed:affiliation |
The University of Iowa, College of Medicine, Department of Pharmacology, Iowa City 52242, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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