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rdf:type |
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lifeskim:mentions |
umls-concept:C0013878,
umls-concept:C0039195,
umls-concept:C0042210,
umls-concept:C0205177,
umls-concept:C0205263,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C2266975
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pubmed:issue |
7-8
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pubmed:dateCreated |
1999-5-27
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pubmed:abstractText |
Using a bipalmitoylated lipopeptide consisting of an ovalbumin helper T-cell epitope covalently linked to an influenza virus cytotoxic T-lymphocyte (CTL) epitope, we addressed possible factors that may be critical for CTL induction. Antigen processing of lipopeptide appears to be required for T-cell induction since there was virtually no in vitro binding of lipopeptide to purified MHC molecules. A major portion of lipopeptide immunogenicity was due to its particulate nature inasmuch as CTL induction in mice correlated with insoluble lipopeptide constructs, whereas more soluble analogs were significantly less immunogenic. Immunohistological analysis of tissue from immunized animals revealed that lipopeptide migration from the s.c. injection site to the spleen could be detected as early as 1 h after immunization and cell-associated lipopeptide was observed on macrophages and dendritic cells, implicating both cell populations in the processing and presentation of lipopeptide particles to CTLs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-2K(K) antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/I-Ad antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NP protein, Influenza A virus,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:ArrheniusTT,
pubmed-author:ChesnutR WRW,
pubmed-author:DahlbergCC,
pubmed-author:FujinamiR SRS,
pubmed-author:IshiokaG YGY,
pubmed-author:KuangL QLQ,
pubmed-author:KuboR TRT,
pubmed-author:OseroffCC,
pubmed-author:RuppertJJ,
pubmed-author:SettiEE,
pubmed-author:SouthwoodSS,
pubmed-author:TsunodaII
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
675-85
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10067673-Amino Acid Sequence,
pubmed-meshheading:10067673-Animals,
pubmed-meshheading:10067673-Epitopes, T-Lymphocyte,
pubmed-meshheading:10067673-Female,
pubmed-meshheading:10067673-H-2 Antigens,
pubmed-meshheading:10067673-Histocompatibility Antigens Class II,
pubmed-meshheading:10067673-Influenza Vaccines,
pubmed-meshheading:10067673-Lipoproteins,
pubmed-meshheading:10067673-Lymphocyte Activation,
pubmed-meshheading:10067673-Mast-Cell Sarcoma,
pubmed-meshheading:10067673-Mice,
pubmed-meshheading:10067673-Mice, Inbred BALB C,
pubmed-meshheading:10067673-Mice, Inbred C57BL,
pubmed-meshheading:10067673-Mice, Inbred DBA,
pubmed-meshheading:10067673-Molecular Sequence Data,
pubmed-meshheading:10067673-Nucleoproteins,
pubmed-meshheading:10067673-Ovalbumin,
pubmed-meshheading:10067673-Particle Size,
pubmed-meshheading:10067673-Peptide Fragments,
pubmed-meshheading:10067673-RNA-Binding Proteins,
pubmed-meshheading:10067673-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10067673-Tumor Cells, Cultured,
pubmed-meshheading:10067673-Viral Core Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Lipopeptide particles as the immunologically active component of CTL inducing vaccines.
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pubmed:affiliation |
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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