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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-15
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pubmed:abstractText |
The usefulness of the lymphocyte transformation test (LTT) for the analysis of adverse reactions to antituberculous drugs was evaluated. - The LTT was performed with isoniazid and rifampicin in 15 tuberculosis and 2 MOTT (Mycobacteria other than tuberculosis)-infection patients who suffered drug reactions, in 23 patients without any adverse reactions, in 7 controls previously exposed to antituberculous drugs, and in 14 controls who had never been exposed. 4/15 of the hepatotoxic reactions only showed a positive LTT with rifampicin, 3/15 only with isoniazid, and in 8/15 the LTT was negative. In an anaphylactoid shock reaction the LTT was extremely exaggerated for both rifampicin and isoniazid. In patients without any side effects only one slightly increased LTT due to isoniazid was observed. Two healthy controls with previous contact to these drugs showed a positive LTT for isoniazid, one of those with both rifampicin and isoniazid. The LTT was negative in all control persons without any former contact to antituberculous medications. In most cases hepatotoxicity seems to be a pure toxic reaction without the participation of cellular immune mechanisms. LTT can be useful for identifying the drug responsible for immunological side effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0949-2321
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10066642-Adult,
pubmed-meshheading:10066642-Anaphylaxis,
pubmed-meshheading:10066642-Anti-Bacterial Agents,
pubmed-meshheading:10066642-Antitubercular Agents,
pubmed-meshheading:10066642-Bromodeoxyuridine,
pubmed-meshheading:10066642-Cells, Cultured,
pubmed-meshheading:10066642-DNA Replication,
pubmed-meshheading:10066642-Drug Eruptions,
pubmed-meshheading:10066642-Drug Hypersensitivity,
pubmed-meshheading:10066642-Drug Therapy, Combination,
pubmed-meshheading:10066642-Drug-Induced Liver Injury,
pubmed-meshheading:10066642-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10066642-Female,
pubmed-meshheading:10066642-Humans,
pubmed-meshheading:10066642-Immunity, Cellular,
pubmed-meshheading:10066642-Isoniazid,
pubmed-meshheading:10066642-Kidney Diseases,
pubmed-meshheading:10066642-Leukocytes, Mononuclear,
pubmed-meshheading:10066642-Lymphocyte Activation,
pubmed-meshheading:10066642-Male,
pubmed-meshheading:10066642-Middle Aged,
pubmed-meshheading:10066642-Mycobacterium Infections,
pubmed-meshheading:10066642-Mycobacterium Infections, Nontuberculous,
pubmed-meshheading:10066642-Mycobacterium kansasii,
pubmed-meshheading:10066642-Nervous System Diseases,
pubmed-meshheading:10066642-Rifampin,
pubmed-meshheading:10066642-Tuberculosis
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pubmed:year |
1999
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pubmed:articleTitle |
Lymphocyte transformation test for the evaluation of adverse effects of antituberculous drugs.
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pubmed:affiliation |
Medical Hospital, Research Centre Borstel, Parkallee 35, D-23845 Borstel, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports,
Research Support, Non-U.S. Gov't
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