Linked Life Data

10065636

Source:http://linkedlifedata.com/resource/pubmed/id/10065636

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-9-2
pubmed:abstractText
This review highlights striking similarities in the down-regulated inflammatory responses that are observed in chronic infectious diseases. It is clear that peripheral mononuclear cells show poor antigen-specific T cell proliferation in lymphatic filariasis as well as schistosomiasis. With respect to cytokines both Th1- and Th2-type products are down-regulated during chronic infection. Drug treatment restores responsiveness in both diseases indicating a link between infection and immune suppression. Interestingly, immunological responses in subjects carrying recent infections are characterized by strong proliferation to parasite antigen and IFN-gamma production. These heightened responses are gradually down-regulated with increased length of exposure to infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-15
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis.
pubmed:affiliation
Department of Parasitology, Leiden University Medical Center, The Netherlands. maria@rullf2.medfacleidenuniv.nl
pubmed:publicationType
Journal Article, Review