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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0019564,
umls-concept:C0023870,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0086045,
umls-concept:C0178719,
umls-concept:C0441655,
umls-concept:C0442805,
umls-concept:C0547047,
umls-concept:C0596019
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
Under the conditions of stimulated phosphatidylinositol turnover (0. 1 mM carbachol plus 20 mM KCl), LiCl (0.1-10 mM) reduced the activity of Cl--ATPase in cultured rat hippocampal neurons without affecting Na+/K+- or anion-insensitive Mg2+-ATPase. This inhibition of Cl--ATPase was attenuated by the addition of 0.5 mM inositol to culture media. The intracellular Cl- concentrations of the LiCl-treated neurons increased in an inositol-sensitive manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Anion Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Antimanic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ca(2 ) Mg(2 )-ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/N-(ethoxycarbonylmethyl)-6-methoxyqu...,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolinium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/anion-sensitive ATPases
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Elsevier Science B.V.
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
821
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10064842-Adenosine Triphosphatases,
pubmed-meshheading:10064842-Animals,
pubmed-meshheading:10064842-Anion Transport Proteins,
pubmed-meshheading:10064842-Antimanic Agents,
pubmed-meshheading:10064842-Biological Transport,
pubmed-meshheading:10064842-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:10064842-Cells, Cultured,
pubmed-meshheading:10064842-Chlorides,
pubmed-meshheading:10064842-Dose-Response Relationship, Drug,
pubmed-meshheading:10064842-Enzyme Activation,
pubmed-meshheading:10064842-Fluorescent Dyes,
pubmed-meshheading:10064842-Hippocampus,
pubmed-meshheading:10064842-Inositol,
pubmed-meshheading:10064842-Lithium Chloride,
pubmed-meshheading:10064842-Pyramidal Cells,
pubmed-meshheading:10064842-Quinolinium Compounds,
pubmed-meshheading:10064842-Rats,
pubmed-meshheading:10064842-Rats, Wistar,
pubmed-meshheading:10064842-Sodium-Potassium-Exchanging ATPase
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pubmed:year |
1999
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pubmed:articleTitle |
Lithium decreases Cl--ATPase activity and increases intracellular Cl- concentration in cultured rat hippocampal neurons.
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pubmed:affiliation |
Department of Pharmacology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8506, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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