| pubmed-article:10064084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10064084 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10064084 | lifeskim:mentions | umls-concept:C0017154 | lld:lifeskim |
| pubmed-article:10064084 | lifeskim:mentions | umls-concept:C1136169 | lld:lifeskim |
| pubmed-article:10064084 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:10064084 | lifeskim:mentions | umls-concept:C0205232 | lld:lifeskim |
| pubmed-article:10064084 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10064084 | pubmed:dateCreated | 1999-3-16 | lld:pubmed |
| pubmed-article:10064084 | pubmed:abstractText | Thymectomy at day 3 of life (d3Tx) results in the development of organ-specific autoimmunity. We have recently shown that d3Tx BALB/c mice which develop autoimmune gastritis contain CD4+ T cells specific for the gastric parietal cell proton pump, H/K ATPase. Here, we demonstrate that freshly explanted gastric lymph node (LN) cells from d3Tx mice react significantly to the H/K ATPase alpha chain, but only marginally to the beta chain. Two H/K ATPase-reactive T cell lines were derived from the gastric LN of d3Tx mice. Both are CD4+, TCR alpha/beta-, and I-Ad restricted, and recognize distinct peptides from the H/K ATPase alpha chain. One cell line secretes Th1 and the other Th2 cytokines, but both are equally potent in inducing gastritis with distinct profiles of cellular infiltration in nu/nu recipient animals. Neither of the cell lines induced disease in normal BALB/c recipients and transfer of disease to nu/nu recipients was blocked by co-transfer of normal BALB/c spleen cells containing CD4+ CD25+ cells. Although CD4+ CD25+ T cells are thought to emigrate from the thymus after day 3 of life, they could be identified in LN of 2-day-old animals. The capacity of CD4+ CD25+ T cells to abrogate the pathogenic activity in vivo of both activated Th1/Th2 lines strongly suggests that this suppressor T cell population may have a therapeutic role in other models of established autoimmunity. The availability of well-characterized lines of autoantigen-specific T cells should greatly facilitate the analysis of the mechanism of action and target of the CD4+ CD25+ immunoregulatory cells. | lld:pubmed |
| pubmed-article:10064084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10064084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10064084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10064084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10064084 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10064084 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:ShevachE MEM | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:McHughRR | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:MarguliesD... | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:NatarajanKK | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:Suri-PayerEE | lld:pubmed |
| pubmed-article:10064084 | pubmed:author | pubmed-author:AmarA ZAZ | lld:pubmed |
| pubmed-article:10064084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10064084 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10064084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10064084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10064084 | pubmed:pagination | 669-77 | lld:pubmed |
| pubmed-article:10064084 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
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| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:meshHeading | pubmed-meshheading:10064084... | lld:pubmed |
| pubmed-article:10064084 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10064084 | pubmed:articleTitle | Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. | lld:pubmed |
| pubmed-article:10064084 | pubmed:affiliation | Cellular Immunology Section, Laboratory of Immunology, NIAID, NIH, Bethesda 20892-1892, USA. | lld:pubmed |
| pubmed-article:10064084 | pubmed:publicationType | Journal Article | lld:pubmed |
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