Linked Life Data

10053172

Source:http://linkedlifedata.com/resource/pubmed/id/10053172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-4-13
pubmed:abstractText
Effects of stage of development and 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein concentrations in reproductive organs of male rats were determined. AhR protein levels in developing rat ventral and dorsolateral prostate decreased with age, declining approximately 70% between Postnatal Days (PND) 1 and 21. ARNT protein levels also decreased with age in dorsolateral, but not ventral prostate. The developmental decreases in prostatic AhR and ARNT protein were associated with decreases in AhR and ARNT mRNA. AhR and ARNT protein concentrations in fetal urogenital sinus on Gestation Days (GD) 16, 18, and 20 were similar to levels in ventral prostate on PND 7. TCDD exposure of adult male rats (0.2, 1, 5, or 25 micrograms/kg po, 24 h) decreased AhR but not ARNT protein in ventral and dorsolateral prostate, vas deferens, and epididymis. In utero and lactational TCDD exposure (1.0 micrograms/kg dam po, GD 15) did not alter ARNT levels but reduced prostatic AhR protein levels on PND 7 and delayed the developmental decrease in AhR protein in ventral and dorsolateral prostate. Finally, pretreatment of rat pups for 24 h with TCDD (5 micrograms/kg ip) down-regulated prostatic AhR protein on PND 7, but not on PND 1. Thus, prostatic AhR and ARNT protein and mRNA levels are regulated with age, whereas only AhR protein concentration is altered by TCDD exposure. Because in utero and lactational TCDD exposure only decreased prostatic AhR on PND 7, it is unlikely that down-regulation of AhR is the mechanism by which perinatal TCDD exposure impairs prostate development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0041-008X
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-89
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10053172-Animals, pubmed-meshheading:10053172-Animals, Newborn, pubmed-meshheading:10053172-Aryl Hydrocarbon Receptor Nuclear Translocator, pubmed-meshheading:10053172-DNA-Binding Proteins, pubmed-meshheading:10053172-Down-Regulation, pubmed-meshheading:10053172-Embryonic and Fetal Development, pubmed-meshheading:10053172-Environmental Pollutants, pubmed-meshheading:10053172-Female, pubmed-meshheading:10053172-Lactation, pubmed-meshheading:10053172-Liver, pubmed-meshheading:10053172-Male, pubmed-meshheading:10053172-Pregnancy, pubmed-meshheading:10053172-Prostate, pubmed-meshheading:10053172-RNA, Messenger, pubmed-meshheading:10053172-Rats, pubmed-meshheading:10053172-Rats, Sprague-Dawley, pubmed-meshheading:10053172-Receptors, Aryl Hydrocarbon, pubmed-meshheading:10053172-Tetrachlorodibenzodioxin, pubmed-meshheading:10053172-Transcription Factors, pubmed-meshheading:10053172-Urogenital System
pubmed:year
1999
pubmed:articleTitle
Ah receptor and ARNT protein and mRNA concentrations in rat prostate: effects of stage of development and 2,3,7, 8-tetrachlorodibenzo-p-dioxin treatment.
pubmed:affiliation
School of Pharmacy, University of Wisconsin, Madison, Wisconsin, 53706, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't