Linked Life Data

10052453

Source:http://linkedlifedata.com/resource/pubmed/id/10052453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-3-18
pubmed:abstractText
Steroid hormones may enter cells by diffusion through the plasma membrane. However, we demonstrate here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. We show that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation of 1,25-(OH)2 vitamin D3, a regulator of the calcium metabolism. Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-15
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10052453-Animals, pubmed-meshheading:10052453-Bone Development, pubmed-meshheading:10052453-Cytochrome P-450 CYP27A1, pubmed-meshheading:10052453-Endocytosis, pubmed-meshheading:10052453-Heymann Nephritis Antigenic Complex, pubmed-meshheading:10052453-Humans, pubmed-meshheading:10052453-Iodine Radioisotopes, pubmed-meshheading:10052453-Kidney Tubules, Proximal, pubmed-meshheading:10052453-Membrane Glycoproteins, pubmed-meshheading:10052453-Mice, pubmed-meshheading:10052453-Mice, Knockout, pubmed-meshheading:10052453-Microscopy, Electron, pubmed-meshheading:10052453-Receptors, LDL, pubmed-meshheading:10052453-Steroid Hydroxylases, pubmed-meshheading:10052453-Vitamin D, pubmed-meshheading:10052453-Vitamin D Deficiency, pubmed-meshheading:10052453-Vitamin D-Binding Protein
pubmed:year
1999
pubmed:articleTitle
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
pubmed:affiliation
Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't