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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-4-15
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pubmed:abstractText |
Bruton's tyrosine kinase (Btk) plays pivotal roles in mast cell activation as well as in B cell development. Btk mutations lead to severe impairments in proinflammatory cytokine production induced by cross-linking of high-affinity IgE receptor on mast cells. By using an in vitro assay to measure the activity that blocks the interaction between protein kinase C and the pleckstrin homology domain of Btk, terreic acid (TA) was identified and characterized in this study. This quinone epoxide specifically inhibited the enzymatic activity of Btk in mast cells and cell-free assays. TA faithfully recapitulated the phenotypic defects of btk mutant mast cells in high-affinity IgE receptor-stimulated wild-type mast cells without affecting the enzymatic activities and expressions of many other signaling molecules, including those of protein kinase C. Therefore, this study confirmed the important roles of Btk in mast cell functions and showed the usefulness of TA in probing into the functions of Btk in mast cells and other immune cell systems. Another insight obtained from this study is that the screening method used to identify TA is a useful approach to finding more efficacious Btk inhibitors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-1370575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-1375248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-1991831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-2521376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-2808186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-3131594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7504992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7506729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7518558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7522330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7524075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7528327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7538439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7561053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7730640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7876149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-7888063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8071371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8119935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8236453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8254195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8332900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8332901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8380905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8400883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8420951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8425221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8476425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8517921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8609388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8629002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8662803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-8910399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9036988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9108083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9148913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9391111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9417097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9471728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9524119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9524120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9547335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9556577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10051623-9712046
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agammaglobulinaemia tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/terreic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:FrancoAA,
pubmed-author:FukamachiHH,
pubmed-author:HartmanS ESE,
pubmed-author:HateHH,
pubmed-author:InagakiNN,
pubmed-author:KawakamiTT,
pubmed-author:KawakamiYY,
pubmed-author:KinoshitaEE,
pubmed-author:KitauraJJ,
pubmed-author:Maeda-YamamotoMM,
pubmed-author:NagaiHH,
pubmed-author:SuzukiHH,
pubmed-author:YaoLL
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2227-32
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
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