Linked Life Data

10051411

Source:http://linkedlifedata.com/resource/pubmed/id/10051411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-4-22
pubmed:abstractText
Somatic insertion mutations, such as those caused by the insertion of a proviral element, can contribute to abnormal cell growth by activating cellular proto-oncogenes or inactivating tumor suppressor genes. Lvis1 is a genomic locus frequently disrupted by viral insertion in AKXD B-cell lymphomas (manuscript submitted for publication). To determine whether insertion mutations at Lvis1 affect a known proto-oncogene or tumor suppressor gene, we mapped Lvis1 to distal mouse chromosome 19. A detailed molecular genetic map of this region was constructed, localizing Lvis1 relative to 20 gene and microsatellite markers, 3 of which have not been mapped in the mouse (Nfkb2, Nlz, and Wnt8b). This analysis revealed that Lvis1 maps between two previously identified viral insertion sites, His2 and Frat1, and does not cosegregate with known gene markers. In addition, our study refines the gene order for distal mouse chromosome 19 and expands the comparative map between mouse chromosome 19 and the human chromosome 10q23-q26 homology region.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0888-7543
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A mouse chromosome 19 genetic map including the Lvis1 viral insertion site.
pubmed:affiliation
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't