Linked Life Data

10051072

Source:http://linkedlifedata.com/resource/pubmed/id/10051072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-5-20
pubmed:abstractText
Progressive renal failure in cirrhosis and fulminant liver disease remains an adverse prognostic factor. Irrespective of the type of renal functional impairment which ranges form "prerenal failure" to "hepatorenal syndrome" and "acute tubular necrosis", renal hypoperfusion, as a consequence of either reduced perfusion pressure or increased renal vascular resistance, is an important pathomechanism. Awareness of the risk of renal failure and avoidance of nephrotoxic agents and of brisk reductions in effective circulating volume are important for prevention. Plasma volume expansion, on the other hand, is mandatory in trying to reverse incipient renal functional impairment. Pharmacological attempts to improve renal hemodynamics by lowering renal and increasing extrarenal vascular resistance have so far largely been disappointing. However, increasing knowledge about mediators and synthesis of specific agonists and antagonists, such as those against endothelin or antidiuretic hormone, may add promising treatment options in the near future. TIPS is another therapeutic tool of potential interest in the management of renal failure in liver disease which needs further evaluation. Renal replacement therapy, preferentially in the form of continuous procedures, may be life-saving in those patients awaiting liver transplantation or spontaneous recovery of their hepatic function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0342-4642
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-14
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Renal failure in liver disease.
pubmed:affiliation
Department of Nephrology and Medical Intensive Care, Charité, Campus Virchow-Klinikum, Humboldt-University, Berlin, Germany. eckardt@charite.de
pubmed:publicationType
Journal Article, Review