Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1999-3-30
pubmed:abstractText
Somatostatin inhibits glucagon-secretion from pancreatic alpha cells but its underlying mechanism is unknown. In mouse alpha cells, we found that somatostatin induced prominent hyperpolarization by activating a K+ channel, which was unaffected by tolbutamide but prevented by pre-treating the cells with pertussis toxin. The K+ channel was activated by intracellular GTP (with somatostatin), GTPgammaS or Gbetagamma subunits. It was thus identified as a G protein-gated K+ (K(G)) channel. RT-PCR and immunohistochemical analyses suggested the K(G) channel to be composed of Kir3.2c and Kir3.4. This study identified a novel ionic mechanism involved in somatostatin-inhibition of glucagon-secretion from pancreatic alpha cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine, http://linkedlifedata.com/resource/pubmed/chemical/G Protein-Coupled..., http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glucagon, http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate, http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly..., http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin, http://linkedlifedata.com/resource/pubmed/chemical/Tolbutamide, http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
444
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10050772-Acetylcholine, pubmed-meshheading:10050772-Animals, pubmed-meshheading:10050772-Electrophysiology, pubmed-meshheading:10050772-Female, pubmed-meshheading:10050772-G Protein-Coupled Inwardly-Rectifying Potassium Channels, pubmed-meshheading:10050772-GTP-Binding Proteins, pubmed-meshheading:10050772-Glucagon, pubmed-meshheading:10050772-Guanosine Triphosphate, pubmed-meshheading:10050772-Immunohistochemistry, pubmed-meshheading:10050772-Ion Channel Gating, pubmed-meshheading:10050772-Islets of Langerhans, pubmed-meshheading:10050772-Mice, pubmed-meshheading:10050772-Mice, Inbred Strains, pubmed-meshheading:10050772-Patch-Clamp Techniques, pubmed-meshheading:10050772-Pertussis Toxin, pubmed-meshheading:10050772-Potassium Channels, pubmed-meshheading:10050772-Potassium Channels, Inwardly Rectifying, pubmed-meshheading:10050772-RNA, Messenger, pubmed-meshheading:10050772-Somatostatin, pubmed-meshheading:10050772-Tolbutamide, pubmed-meshheading:10050772-Virulence Factors, Bordetella
pubmed:year
1999
pubmed:articleTitle
Somatostatin induces hyperpolarization in pancreatic islet alpha cells by activating a G protein-gated K+ channel.
pubmed:affiliation
Department of Pharmacology II, Faculty of Medicine and Graduate School of Medicine, Osaka University, Suita, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't