Linked Life Data

10050717

Source:http://linkedlifedata.com/resource/pubmed/id/10050717

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-3-30
pubmed:abstractText
Of 24 published clinical reports of periodic chronic myelogenous leukaemia (PCML), 21 had sufficient data to analyse for periodicity, and 12 showed significant periodicity (p < or = 0.05) using the Lomb periodogram. Leucocyte oscillations had periods T ranging from 37 to 83d. When data were also reported for platelets and reticulocytes there was no significant difference between their periods and those of the leucocytes. These data and their analysis provide strong circumstantial evidence for a haemopoietic stem cell origin of PCML. Namely, the known chromosomal changes in CML patients may, on occasion, also be accompanied by a destabilization resulting in an oscillatory efflux into the leucocyte, platelet and erythrocytic pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
336-45
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Periodic chronic myelogenous leukaemia: spectral analysis of blood cell counts and aetiological implications.
pubmed:affiliation
Department of Physiology, McGill University, Montreal, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't