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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-11
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pubmed:abstractText |
Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses. Selective recruitment of these two subsets depends on specific adhesion molecules and specific chemoattractants. Here, we demonstrate that the T cell-directed CC chemokine thymus and activation-regulated chemokine (TARC) was abundantly produced by monocytes treated with granulocyte macrophage colony stimulating factor (GM-CSF) or IL-3, especially in the presence of IL-4 and by dendritic cells derived from monocytes cultured with GM-CSF + IL-4. The receptor for TARC and another macrophage/dendritic cell-derived CC chemokine macrophage-derived chemokine (MDC) is CCR4, a G protein-coupled receptor. CCR4 was found to be expressed on approximately 20% of adult peripheral blood effector/memory CD4+ T cells. T cells attracted by TARC and MDC generated cell lines predominantly producing Th2-type cytokines, IL-4 and IL-5. Fractionated CCR4+ cells but not CCR4- cells also selectively gave rise to Th2-type cell lines. When naive CD4+ T cells from adult peripheral blood were polarized in vitro, Th2-type cells selectively expressed CCR4 and vigorously migrated toward TARC and MDC. Taken together, CCR4 is selectively expressed on Th2-type T cells and antigen-presenting cells may recruit Th2 cells expressing CCR4 by producing TARC and MDC in Th2-dominant conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CCL17 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCL22 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL17,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL22,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10050676-Antigen-Presenting Cells,
pubmed-meshheading:10050676-Antigens, CD45,
pubmed-meshheading:10050676-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:10050676-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10050676-Chemokine CCL17,
pubmed-meshheading:10050676-Chemokine CCL22,
pubmed-meshheading:10050676-Chemokines,
pubmed-meshheading:10050676-Chemokines, CC,
pubmed-meshheading:10050676-Chemotaxis, Leukocyte,
pubmed-meshheading:10050676-Dendritic Cells,
pubmed-meshheading:10050676-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10050676-Humans,
pubmed-meshheading:10050676-Immunologic Memory,
pubmed-meshheading:10050676-Interleukin-3,
pubmed-meshheading:10050676-Interleukin-4,
pubmed-meshheading:10050676-Macrophages,
pubmed-meshheading:10050676-Monocytes,
pubmed-meshheading:10050676-Receptors, CCR4,
pubmed-meshheading:10050676-Receptors, Chemokine,
pubmed-meshheading:10050676-T-Lymphocyte Subsets,
pubmed-meshheading:10050676-Th2 Cells,
pubmed-meshheading:10050676-Thymus Gland
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pubmed:year |
1999
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pubmed:articleTitle |
Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.
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pubmed:affiliation |
Shionogi Institute for Medical Science, Settsu, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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