Source:http://linkedlifedata.com/resource/pubmed/id/10049579
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-5-24
|
| pubmed:databankReference | |
| pubmed:abstractText |
Cytoplasmic dynein is a large multisubunit microtubule-based motor protein, which mediates movement of numerous intracellular organelles. We report here the identification of the human homologue of cytoplasmic dynein intermediate chain 1 gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue (Dnci1) was identified along with another highly related gene, Dnci2, and their RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1 was found to have a highly restricted expression domain in the developing forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a broad expression profile throughout the entire central nervous system and most of the PNS. A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
257-67
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:10049579-Amino Acid Sequence,
pubmed-meshheading:10049579-Animals,
pubmed-meshheading:10049579-Base Sequence,
pubmed-meshheading:10049579-Blotting, Northern,
pubmed-meshheading:10049579-Chromosomes, Artificial, Yeast,
pubmed-meshheading:10049579-Dyneins,
pubmed-meshheading:10049579-Embryo, Mammalian,
pubmed-meshheading:10049579-Embryonic and Fetal Development,
pubmed-meshheading:10049579-Humans,
pubmed-meshheading:10049579-In Situ Hybridization,
pubmed-meshheading:10049579-Limb Buds,
pubmed-meshheading:10049579-Mice,
pubmed-meshheading:10049579-Models, Genetic,
pubmed-meshheading:10049579-Molecular Sequence Data,
pubmed-meshheading:10049579-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10049579-Sequence Homology, Amino Acid,
pubmed-meshheading:10049579-Time Factors,
pubmed-meshheading:10049579-Tissue Distribution
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.
|
| pubmed:affiliation |
Department of Molecular and Medical Genetics, University of Toronto, The Hospital for Sick Children, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|