Linked Life Data

10049576

Source:http://linkedlifedata.com/resource/pubmed/id/10049576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-4-20
pubmed:abstractText
The Caenorhabditis elegans body axis, like that of other animals, is patterned by the action of Hox genes. In order to examine the function of one C. elegans Hox gene in depth, we determined the postembryonic expression pattern of egl-5, the C. elegans member of the Abdominal-B Hox gene paralog group, by means of whole-mount staining with a polyclonal antibody. A major site of egl-5 expression and function is in the epithelium joining the posterior digestive tract with the external epidermis. Patterning this region and its derived structures is a conserved function of Abd-B paralog group genes in other animals. Cells that initiate egl-5 expression during embryogenesis are clustered around the presumptive anus. Expression is initiated postembryonically in four additional mesodermal and ectodermal cell lineages or tissues. Once initiated in a lineage, egl-5 expression continues throughout development, suggesting that the action of egl-5 can be regarded as defining a positional cell identity. A variety of cross-regulatory interactions between egl-5 and the next more anterior Hox gene, mab-5, help define the expression domains of their respective gene products. In its expression in a localized body region, function as a marker of positional cell identity, and interactions with another Hox gene, egl-5 resembles Hox genes of other animals. This suggests that C. elegans, in spite of its small cell number and reproducible cell lineages, may not differ greatly from other animals in the way it employs Hox genes for regional specification during development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-28
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10049576-Animals, pubmed-meshheading:10049576-Body Patterning, pubmed-meshheading:10049576-Caenorhabditis elegans, pubmed-meshheading:10049576-Caenorhabditis elegans Proteins, pubmed-meshheading:10049576-Cell Lineage, pubmed-meshheading:10049576-Drosophila Proteins, pubmed-meshheading:10049576-Gene Expression Regulation, Developmental, pubmed-meshheading:10049576-Genes, Helminth, pubmed-meshheading:10049576-Genes, Homeobox, pubmed-meshheading:10049576-Genes, Reporter, pubmed-meshheading:10049576-Gonads, pubmed-meshheading:10049576-Green Fluorescent Proteins, pubmed-meshheading:10049576-Helminth Proteins, pubmed-meshheading:10049576-Homeodomain Proteins, pubmed-meshheading:10049576-Immunohistochemistry, pubmed-meshheading:10049576-Larva, pubmed-meshheading:10049576-Luminescent Proteins, pubmed-meshheading:10049576-Male, pubmed-meshheading:10049576-Mutation, pubmed-meshheading:10049576-Transcription Factors
pubmed:year
1999
pubmed:articleTitle
Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5.
pubmed:affiliation
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't