| pubmed-article:10049517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0024320 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C0206527 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C1519477 | lld:lifeskim |
| pubmed-article:10049517 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:10049517 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10049517 | pubmed:dateCreated | 1999-4-5 | lld:pubmed |
| pubmed-article:10049517 | pubmed:abstractText | Lymphotoxin alpha (LT-alpha) and lymphotoxin beta (LT-beta) are members of the tumour necrosis factor (TNF) ligand family. Because of the importance of TNF in the pathogenesis of septic shock, the expression of LT-alpha and LT-beta mRNA in murine splenocytes stimulated with different pro-inflammatory cytokines, sepsis-associated mediators such as lipopolysaccharide (LPS) and bacterial superantigens was investigated. The authors show that the bacterial superantigens, toxic shock syndrome toxin 1 (TSST-1) and staphylococcal enterotoxin B (SEB) upregulate LT-alpha mRNA expression in vitro in murine cells. Basal expression of LT-beta mRNA was found in unstimulated murine splenocytes, and could be increased by the addition of the mitogen concanavalin A (Con A). Despite this suggested inducibility of the murine LT-beta transcript, sepsis-associated mediators did not affect its regulation. Neither the pro-inflammatory cytokines interleukin 2 (IL-2), TNF-alpha nor LPS alone or in combination with interferon gamma (IFN-gamma) had any effect on LT-beta mRNA expression. The bacterial superantigens TSST-1, SEB and streptococcal pyrogenic exotoxin A (SPEA) were also unable to upregulate LT-beta mRNA transcript, in contrast to the observation with LT-alpha. | lld:pubmed |
| pubmed-article:10049517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10049517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10049517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10049517 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10049517 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:10049517 | pubmed:author | pubmed-author:CohenJJ | lld:pubmed |
| pubmed-article:10049517 | pubmed:author | pubmed-author:PolakJJ | lld:pubmed |
| pubmed-article:10049517 | pubmed:author | pubmed-author:EvansTT | lld:pubmed |
| pubmed-article:10049517 | pubmed:author | pubmed-author:ZinettiMM | lld:pubmed |
| pubmed-article:10049517 | pubmed:author | pubmed-author:AgyekumSS | lld:pubmed |
| pubmed-article:10049517 | pubmed:copyrightInfo | Copyright 1998 Academic Press. | lld:pubmed |
| pubmed-article:10049517 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10049517 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:10049517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10049517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10049517 | pubmed:pagination | 940-7 | lld:pubmed |
| pubmed-article:10049517 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10049517 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:10049517 | pubmed:articleTitle | The role of lipopolysaccharide, pro-inflammatory cytokines and bacterial superantigens in the transcriptional regulation of lymphotoxin alpha and beta in mouse splenocytes. | lld:pubmed |
| pubmed-article:10049517 | pubmed:affiliation | Department of Infectious Diseases, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. | lld:pubmed |
| pubmed-article:10049517 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10049517 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:10049517 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10049517 | lld:pubmed |
