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pubmed-article:10049291pubmed:abstractTextSix patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.lld:pubmed
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pubmed-article:10049291pubmed:articleTitleDeclining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.lld:pubmed
pubmed-article:10049291pubmed:affiliationInstitute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam.lld:pubmed
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