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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1999-2-22
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pubmed:abstractText |
(1) Nitric oxide (NO) synthase inhibitors (NOS-I) such as L-Name (N(G)-nitro L-arginine methyl ester) and L-NMMA (N(G)-monomethyl L-arginine) may enhance anesthesia indirectly by inhibiting the NO pathway. Moreover, NOS-I interact directly with receptor proteins. In an animal study, L-NMMA potentiated muscle relaxants. (2) The present experiments investigate the effects of L-NMMA, L-Name, and L-arginine on the nicotinic acetylcholine receptor channel (nAChR) using patch clamp techniques and a piezo-driven application system. Both NOS-I appear to directly interact with the nAChR in the open as well as in the closed conformation. L-Arginine has no effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-4274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
100-101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-13
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10049129-Animals,
pubmed-meshheading:10049129-Arginine,
pubmed-meshheading:10049129-Cells, Cultured,
pubmed-meshheading:10049129-Electric Stimulation,
pubmed-meshheading:10049129-Enzyme Inhibitors,
pubmed-meshheading:10049129-Ion Channel Gating,
pubmed-meshheading:10049129-Ligands,
pubmed-meshheading:10049129-Mice,
pubmed-meshheading:10049129-Microtubules,
pubmed-meshheading:10049129-Muscle, Skeletal,
pubmed-meshheading:10049129-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:10049129-Nicotinic Antagonists,
pubmed-meshheading:10049129-Nitric Oxide Synthase,
pubmed-meshheading:10049129-Patch-Clamp Techniques,
pubmed-meshheading:10049129-Receptors, Nicotinic,
pubmed-meshheading:10049129-Synaptic Transmission,
pubmed-meshheading:10049129-omega-N-Methylarginine
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pubmed:year |
1998
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pubmed:articleTitle |
The NO synthase inhibitors L-Name and L-NMMA, but not L-arginine, block the mammalian nicotinic acetylcholine receptor channel.
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pubmed:affiliation |
Department of Anesthesiology, Technische Universität München, Klinikum rechts der Isar, Munich, Germany. hajo.schneck@lrz.tu-muenchen.de
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pubmed:publicationType |
Journal Article
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