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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1977-2-16
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|
pubmed:abstractText |
Adenine arabinoside, which inhibits the synthesis of DNA by intracellular Toxoplasma gondii, is more inhibitory to the parasite than it is to cultured human fibroblast host cells. A single-step mutant of T. gondii that is 50-fold more resistant to adenine arabinoside was isolated after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Cytosine arabinoside is notably more inhibitory to cultured human cells than it is to T. gondii. Thus in infected cells treated with cytosine arabinoside and labeled with 3H-deoxyuridine nearly all of the label is specifically incorporated into the intracellular T. gondii.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-3395
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
993-9
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:1003290-Animals,
pubmed-meshheading:1003290-Cells, Cultured,
pubmed-meshheading:1003290-Cytarabine,
pubmed-meshheading:1003290-DNA,
pubmed-meshheading:1003290-Deoxyuridine,
pubmed-meshheading:1003290-Drug Resistance,
pubmed-meshheading:1003290-Mutation,
pubmed-meshheading:1003290-RNA,
pubmed-meshheading:1003290-Thymidine,
pubmed-meshheading:1003290-Toxoplasma,
pubmed-meshheading:1003290-Vidarabine
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|
pubmed:year |
1976
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|
pubmed:articleTitle |
Arabinosyl nucleosides inhibit Toxoplasma gondii and allow the selection of resistant mutants.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
