| pubmed-article:10028017 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C0920350 | lld:lifeskim |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C0312740 | lld:lifeskim |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C0167627 | lld:lifeskim |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C0439667 | lld:lifeskim |
| pubmed-article:10028017 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:10028017 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10028017 | pubmed:dateCreated | 1999-4-7 | lld:pubmed |
| pubmed-article:10028017 | pubmed:abstractText | The interaction of CD40 on antigen presenting cells (APC) with CD40L on mouse thyroglobulin (MTg)-specific T cells may deliver an essential signal for the development of CD4(+) experimental autoimmune thyroiditis (EAT) effector cells and anti-MTg producing B cells. To determine the requirement for CD40-CD40L interactions in G-EAT, donor mice were injected with an anti-CD40L monoclonal antibody (mAb) on days -1, 0, and +1 relative to immunization with MTg and adjuvant. Recipients of spleen cells from MTg-primed donor mice injected with anti-CD40L did not develop EAT, while spleen cells from similarly immunized hamster Ig-treated donors transferred severe G-EAT. Although the decreased EAT severity was accompanied by increased IL-4 mRNA expression by CD4(+) T cells from anti-CD40L-treated donors, the increased IL-4 was not necessary for suppression of EAT, since anti-CD40L treatment prevented EAT in IL-4-deficient mice. Addition of MTg-primed B cells during in vitro activation of spleen cells from anti-CD40L-treated donors did not induce EAT in recipients, suggesting that anti-CD40L suppresses EAT by preventing the sensitization of EAT effector cells. Addition of anti-CD40L during in vitro activation of MTg-primed spleen cells or treatment of recipients with anti-CD40L had no effect on EAT severity, indicating that CD40-CD40L interactions are not required after EAT effector cells are primed to MTg. | lld:pubmed |
| pubmed-article:10028017 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10028017 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10028017 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10028017 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10028017 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:10028017 | pubmed:author | pubmed-author:Braley-Mullen... | lld:pubmed |
| pubmed-article:10028017 | pubmed:author | pubmed-author:PetersonK EKE | lld:pubmed |
| pubmed-article:10028017 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10028017 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10028017 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10028017 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10028017 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10028017 | pubmed:pagination | 1-12 | lld:pubmed |
| pubmed-article:10028017 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10028017 | pubmed:meshHeading | pubmed-meshheading:10028017... | lld:pubmed |
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| pubmed-article:10028017 | pubmed:meshHeading | pubmed-meshheading:10028017... | lld:pubmed |
| pubmed-article:10028017 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10028017 | pubmed:articleTitle | CD40L is necessary for the priming of effector cells for lymphocytic and granulomatous experimental autoimmune thyroiditis. | lld:pubmed |
| pubmed-article:10028017 | pubmed:affiliation | Department of Molecular Microbiology and Immunology, University of Missouri - Columbia, Columbia, MO, 65212, USA. | lld:pubmed |
| pubmed-article:10028017 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10028017 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
