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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-4-16
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pubmed:abstractText |
The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies specific for the other alpha chains of the heterotrimeric type IV collagen probably do not cause disease. In this study, we have investigated whether differences in fine specificity of autoimmune recognition of the alpha3(IV)NC1 correlate with clinical outcome.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
936-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10027930-Anti-Glomerular Basement Membrane Disease,
pubmed-meshheading:10027930-Autoantibodies,
pubmed-meshheading:10027930-Autoantigens,
pubmed-meshheading:10027930-Base Sequence,
pubmed-meshheading:10027930-Case-Control Studies,
pubmed-meshheading:10027930-Cell Line,
pubmed-meshheading:10027930-Cloning, Molecular,
pubmed-meshheading:10027930-Collagen,
pubmed-meshheading:10027930-Collagen Type IV,
pubmed-meshheading:10027930-DNA Primers,
pubmed-meshheading:10027930-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10027930-Epitope Mapping,
pubmed-meshheading:10027930-Humans,
pubmed-meshheading:10027930-Immunodominant Epitopes,
pubmed-meshheading:10027930-Prognosis,
pubmed-meshheading:10027930-Protein Conformation,
pubmed-meshheading:10027930-Recombinant Fusion Proteins,
pubmed-meshheading:10027930-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease.
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pubmed:affiliation |
Department of Nephrology, Lund University, Lund, Sweden. Thomas.Hellmark@njur.lu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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