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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-4-16
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pubmed:abstractText |
The renin-angiotensin system is thought to be involved in the progression of glomerulonephritis (GN) into end-stage renal failure (ESRF) because of the observed renoprotective effects of angiotensin-converting enzyme inhibitors (ACEIs). However, ACEIs have pharmacological effects other than ACE inhibition that may help lower blood pressure and preserve glomerular structure. We previously reported a new animal model of progressive glomerulosclerosis induced by a single intravenous injection of an anti-Thy-1 monoclonal antibody, MoAb 1-22-3, in uninephrectomized rats. Using this new model of progressive GN, we examined the hypothesis that ACEIs prevent the progression to ESRF by modulating the effects of angiotensin II (Ang II) on the production of transforming growth factor-beta (TGF-beta) and extracellular matrix components.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Cilazapril,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Hydralazine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/candesartan,
http://linkedlifedata.com/resource/pubmed/chemical/icatibant
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
877-89
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10027924-Angiotensin II,
pubmed-meshheading:10027924-Angiotensin Receptor Antagonists,
pubmed-meshheading:10027924-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:10027924-Animals,
pubmed-meshheading:10027924-Antihypertensive Agents,
pubmed-meshheading:10027924-Benzimidazoles,
pubmed-meshheading:10027924-Bradykinin,
pubmed-meshheading:10027924-Cilazapril,
pubmed-meshheading:10027924-Collagen,
pubmed-meshheading:10027924-Disease Models, Animal,
pubmed-meshheading:10027924-Glomerulonephritis, Membranoproliferative,
pubmed-meshheading:10027924-Hydralazine,
pubmed-meshheading:10027924-Kidney Failure, Chronic,
pubmed-meshheading:10027924-Male,
pubmed-meshheading:10027924-Proteinuria,
pubmed-meshheading:10027924-Rats,
pubmed-meshheading:10027924-Rats, Wistar,
pubmed-meshheading:10027924-Receptors, Bradykinin,
pubmed-meshheading:10027924-Renal Circulation,
pubmed-meshheading:10027924-Renin-Angiotensin System,
pubmed-meshheading:10027924-Tetrazoles,
pubmed-meshheading:10027924-Transforming Growth Factor beta
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pubmed:year |
1999
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pubmed:articleTitle |
Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis.
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pubmed:affiliation |
Division of Blood Transfusion, Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan. nakamura@res.yamanashi-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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