Linked Life Data

10027555

Source:http://linkedlifedata.com/resource/pubmed/id/10027555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-6-14
pubmed:abstractText
A recent observation has shown that a common polymorphism (-491 A) in the promoter of apolipoprotein E (APOE) was associated with an increased risk for Alzheimer's disease (AD) in European decent. Moreover, the promoter with -491 A showed higher transcriptional activity than that with -491 T. To investigate the further contribution of the polymorphism to the etiology of sporadic AD, we evaluated associations between Japanese AD and -491 A/T polymorphism of APOE. There was no significant difference between these cases and controls. The percentage of the homozygote of -491 A allele (AA) among the Japanese control population was significantly higher than that among the Spanish control population. The APOE promoter genotype frequencies may be influenced by the ethnic background. Our study failed to confirm any relationship between -491 A/T polymorphism and AD. Thus, we conclude that the APOE promoter polymorphism does not represent an additional risk factor for AD in Japanese populations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
259
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population.
pubmed:affiliation
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
pubmed:publicationType
Journal Article