|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1999-3-3
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Activation of the type I TGFbeta receptor (TbetaR-I) requires phosphorylation of a regulatory segment known as the GS region, located upstream of the serine/threonine kinase domain in the cytoplasmic portion of the receptor. The crystal structure of a fragment of unphosphorylated TbetaR-I, containing both the GS region and the catalytic domain, has been determined in complex with the FK506-binding protein FKBP12. TbetaR-I adopts an inactive conformation that is maintained by the unphosphorylated GS region. FKBP12 binds to the GS region of the receptor, capping the TbetaR-II phosphorylation sites and further stabilizing the inactive conformation of TbetaR-I. Certain structural features at the catalytic center of TbetaR-I are characteristic of tyrosine kinases rather than Ser/Thr kinases.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
96
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
425-36
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10025408-Activin Receptors, Type I,
pubmed-meshheading:10025408-Amino Acid Sequence,
pubmed-meshheading:10025408-Crystallography, X-Ray,
pubmed-meshheading:10025408-Cytoplasm,
pubmed-meshheading:10025408-Dimerization,
pubmed-meshheading:10025408-Enzyme Activation,
pubmed-meshheading:10025408-Humans,
pubmed-meshheading:10025408-Immunophilins,
pubmed-meshheading:10025408-Models, Molecular,
pubmed-meshheading:10025408-Molecular Sequence Data,
pubmed-meshheading:10025408-Peptide Fragments,
pubmed-meshheading:10025408-Protein Conformation,
pubmed-meshheading:10025408-Protein Structure, Secondary,
pubmed-meshheading:10025408-Protein Structure, Tertiary,
pubmed-meshheading:10025408-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10025408-Protein-Tyrosine Kinases,
pubmed-meshheading:10025408-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:10025408-Tacrolimus Binding Proteins
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.
|
|
pubmed:affiliation |
Laboratories of Molecular Biophysics, Rockefeller University, New York, New York 10021, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
