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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-7-21
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pubmed:abstractText |
To study the association between anti-Gag and anti-Nef antibody reactivities and their correlations with disease progression, 174 HIV-1/AIDS patients were followed up for 1 year after they received triple therapy. The antibody reactivities were analyzed using a Western blot test with recombinant Gag and Nef proteins. The results showed that decreasing levels of anti-Gag or anti-Nef antibody correlate with disease progression defined by HIV-1 viral loads or T4 cell counts. After receiving triple treatment for 1 year, 8 of 38 (21.1%) Nef antibody-negative patients became positive, while only 9 of 125 (7.2%) Nef antibody-positive persons lost the antibody reactivity (p < 0.01). Therefore, HIV-1 Nef may serve as a clinical marker of disease progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0889-2229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-50
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10024051-Blotting, Western,
pubmed-meshheading:10024051-CD4 Lymphocyte Count,
pubmed-meshheading:10024051-Disease Progression,
pubmed-meshheading:10024051-Gene Products, gag,
pubmed-meshheading:10024051-Gene Products, nef,
pubmed-meshheading:10024051-HIV Antibodies,
pubmed-meshheading:10024051-HIV Infections,
pubmed-meshheading:10024051-HIV-1,
pubmed-meshheading:10024051-Humans,
pubmed-meshheading:10024051-RNA, Viral,
pubmed-meshheading:10024051-Recombinant Fusion Proteins,
pubmed-meshheading:10024051-Viral Load,
pubmed-meshheading:10024051-nef Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1999
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pubmed:articleTitle |
Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression.
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pubmed:affiliation |
AIDS Prevention and Research Center, National Yang-Ming University, Taipei, Taiwan, Republic of China. arthur@ym.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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