Source:http://linkedlifedata.com/resource/pubmed/id/10023514
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1999-5-7
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pubmed:abstractText |
Prepulse inhibition (PPI) and habituation of the startle response are operational measures of sensorimotor gating and information processing. Changes in the normal inhibition and habituation of the startle response may provide trait markers for illnesses such as schizophrenia that have altered neurotransmitter control of the neural circuitry that modulates these measures. The stability of PPI and habituation was assessed in 10 normal male subjects. Prepulse inhibition was found to be most stable in the more intense prepulse conditions, and habituation was most stable in the early portion of the test session. These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3223
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
360-4
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:10023514-Acoustic Stimulation,
pubmed-meshheading:10023514-Adult,
pubmed-meshheading:10023514-Analysis of Variance,
pubmed-meshheading:10023514-Electroencephalography,
pubmed-meshheading:10023514-Habituation, Psychophysiologic,
pubmed-meshheading:10023514-Humans,
pubmed-meshheading:10023514-Image Processing, Computer-Assisted,
pubmed-meshheading:10023514-Longitudinal Studies,
pubmed-meshheading:10023514-Male,
pubmed-meshheading:10023514-Middle Aged,
pubmed-meshheading:10023514-Neural Inhibition,
pubmed-meshheading:10023514-Reaction Time,
pubmed-meshheading:10023514-Sensory Thresholds,
pubmed-meshheading:10023514-Startle Reaction
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pubmed:year |
1999
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pubmed:articleTitle |
Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population.
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pubmed:affiliation |
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0804, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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