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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-13
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pubmed:abstractText |
A chimeric immune receptor consisting of an extracellular antigen-binding domain derived from the CC49 humanized single-chain antibody, linked to the CD3zeta signaling domain of the T cell receptor, was generated (CC49-zeta). This receptor binds to TAG-72, a mucin antigen expressed by most human adenocarcinomas. CC49-zeta was expressed in CD4+ and CD8+ T cells and induced cytokine production on stimulation. Human T cells expressing CC49-zeta recognized and killed tumor cell lines and primary tumor cells expressing TAG-72. CC49-zeta T cells did not mediate bystander killing of TAG-72-negative cells. In addition, CC49-zeta T cells not only killed FasL-positive tumor cells in vitro and in vivo, but also survived in their presence, and were immunoprotective in intraperitoneal and subcutaneous murine tumor xenograft models with TAG-72-positive human tumor cells. Finally, receptor-positive T cells were still effective in killing TAG-72-positive targets in the presence of physiological levels of soluble TAG-72, and did not induce killing of TAG-72-negative cells under the same conditions. This approach is being currently being utilized in a phase I clinical trial for the treatment of colon cancer.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/B72.3 antibody,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tumor-associated antigen 72
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1043-0342
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10022542-Animals,
pubmed-meshheading:10022542-Antibodies, Neoplasm,
pubmed-meshheading:10022542-Antigens, Neoplasm,
pubmed-meshheading:10022542-Cell Division,
pubmed-meshheading:10022542-Fas Ligand Protein,
pubmed-meshheading:10022542-Glycoproteins,
pubmed-meshheading:10022542-Humans,
pubmed-meshheading:10022542-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:10022542-Membrane Glycoproteins,
pubmed-meshheading:10022542-Mice,
pubmed-meshheading:10022542-Mice, Inbred NOD,
pubmed-meshheading:10022542-Mice, SCID,
pubmed-meshheading:10022542-Receptors, Immunologic,
pubmed-meshheading:10022542-Recombinant Fusion Proteins,
pubmed-meshheading:10022542-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor.
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pubmed:affiliation |
Department of Preclinical Biology and Immunology, Cell Genesys, Inc., Foster City, CA 94404, USA.
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pubmed:publicationType |
Journal Article
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