Linked Life Data

10022292

Source:http://linkedlifedata.com/resource/pubmed/id/10022292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-2-25
pubmed:abstractText
DNA adducts are nucleotide bases that have been covalently modified by reactive electrophilic chemical intermediates, and have been extensively researched for their role in mutagenesis and carcinogenesis. However, many DNA adduct measurement techniques have difficulty in the quantification of adducts at realistic human exposure levels. We are using the extremely sensitive analytical technique of accelerator mass spectrometry (AMS) to study adducts either at low dose or directly in humans. AMS is a technique for measuring isotope ratios with high selectivity, attomole sensitivity (10(-18) mol) and precision of 0.5-10%, depending on isotope level and preparation method. This sensitivity and precision is being used to study the dose-response, toxicokinetics, and toxicodynamics of DNA adduct formation and removal following administration of very low doses of chemicals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
102-103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification.
pubmed:affiliation
Biology and Biotechnology Research Program and Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't