Linked Life Data

10022211

Source:http://linkedlifedata.com/resource/pubmed/id/10022211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-4-27
pubmed:abstractText
In this article, we report the identification and quantitation of cocaine N-oxide (CNO), a thermally labile oxidative metabolite, from both animal and human samples. The concentration of CNO is similar to the concentrations of cocaine in the samples analyzed. The technique used for the determination of CNO in this study is liquid chromatography-electrospray ionization mass spectrometry, which is necessary because CNO is converted to cocaine upon heating. This includes simple heating of aqueous solutions to temperatures in excess of 100 degrees C and analysis by gas chromatography-mass spectrometry (GC-MS), in which CNO is converted to cocaine in the injection port. The thermal conversion of CNO to cocaine is estimated to cause an over-reporting of cocaine levels by 10-20% when using GC-MS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-4760
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
62-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Identification and quantification of cocaine N-oxide: a thermally labile metabolite of cocaine.
pubmed:affiliation
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens 30602-2352, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't