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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-11
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pubmed:abstractText |
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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|
pubmed:volume |
9
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|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-54
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10021939-Amino Acids,
pubmed-meshheading:10021939-Animals,
pubmed-meshheading:10021939-Disease Models, Animal,
pubmed-meshheading:10021939-Electroshock,
pubmed-meshheading:10021939-Hydrobromic Acid,
pubmed-meshheading:10021939-Hydrochloric Acid,
pubmed-meshheading:10021939-Hydroxy Acids,
pubmed-meshheading:10021939-Inhibitory Concentration 50,
pubmed-meshheading:10021939-Mice,
pubmed-meshheading:10021939-N-Methylaspartate,
pubmed-meshheading:10021939-Phosphonic Acids,
pubmed-meshheading:10021939-Quinoxalines,
pubmed-meshheading:10021939-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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pubmed:year |
1999
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pubmed:articleTitle |
N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
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pubmed:affiliation |
Novartis Pharma AG, Basel, Switzerland. yves.auberson@pharma.novartis.com
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pubmed:publicationType |
Journal Article
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