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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-11
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pubmed:abstractText |
A hammerhead ribozyme has been labeled with a fluorescein reporter dye which enables the nucleic acid to detect binding of small organic compounds such as neomycin. The fluorescent changes are associated with conformational changes in the RNA and can be used to determine the binding modes of the drugs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10021931-Anti-Bacterial Agents,
pubmed-meshheading:10021931-Carrier Proteins,
pubmed-meshheading:10021931-Dose-Response Relationship, Drug,
pubmed-meshheading:10021931-Drug Design,
pubmed-meshheading:10021931-Fluorescein,
pubmed-meshheading:10021931-Framycetin,
pubmed-meshheading:10021931-Models, Biological,
pubmed-meshheading:10021931-Protein Conformation,
pubmed-meshheading:10021931-RNA,
pubmed-meshheading:10021931-RNA, Catalytic,
pubmed-meshheading:10021931-Spectrometry, Fluorescence
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pubmed:year |
1999
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pubmed:articleTitle |
RNA-aminoglycoside antibiotic interactions: fluorescence detection of binding and conformational change.
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pubmed:affiliation |
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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